Kinozapasco 2021 centered on themes of cultural resilience, social justice, and indigenous sovereignty. Films showcased explored pressing issues such as environmental activism, gender equity, and the interplay between tradition and modernity. The festival prioritized works by indigenous filmmakers, ensuring narratives were told from authentic perspectives across languages like Zapotec, Mixtec, and Triqui. Subtitles and interpretive guides were provided to bridge linguistic and cultural divides.