The film follows Columbus (Jesse Eisenberg), Wichita (Zoe Kravitz), Little Rock (Avan Jogia), and Tallahassee (Woody Harrelson) as they embark on a new adventure. The group reunites with a familiar face, Madison (Aubrey Plaza), and they soon find themselves on a mission to find a zombie-free White House. Along the way, they encounter new challenges, including more evolved and faster zombies, as well as a new group of survivors led by Berkeley (Avan Jogia) and a clone of Tallahassee.